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Microfracture in Cartilage Repair: Efficacy, Adverse Outcomes, and Clinical ControversiesMicrofracture Technique: Limitations and Concerns. This article discusses the limitations and potential adverse outcomes associated with the microfracture technique used for cartilage repair. Concerns include subchondral bone overgrowth, formation of less durable fibrocartilage instead of hyaline cartilage, and the lack of long-term durability. Other limitations include the technique's suitability for…Microfracture Technique: Limitations and Concerns. This article discusses the limitations and potential adverse outcomes associated with the microfracture technique used for cartilage repair. Concerns include subchondral bone overgrowth, formation of less durable fibrocartilage instead of hyaline cartilage, and the lack of long-term durability. Other limitations include the technique's suitability for large lesions, the formation of granulation tissue and subchondral cysts, and the need for extended rehabilitation. These factors raise concerns about the efficacy and long-term outcomes of microfracture as a sole treatment for cartilage defects.
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Tanvi Verma
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Cellular epigenetics studies how gene activity changes without altering DNA sequences, influenced by chemical modifications like DNA methylation and histone modification. These epigenetic marks regulate gene expression, impacting development, disease prevention, and response to environment. Lifestyle factors such as diet, physical activity, and stress management can positively affect epigenetic patterns,…Cellular epigenetics studies how gene activity changes without altering DNA sequences, influenced by chemical modifications like DNA methylation and histone modification. These epigenetic marks regulate gene expression, impacting development, disease prevention, and response to environment. Lifestyle factors such as diet, physical activity, and stress management can positively affect epigenetic patterns, potentially reducing risks for cancer, diabetes, and neurological disorders. Abnormal epigenetic changes may lead to serious health conditions and can sometimes be inherited, highlighting the importance of early detection and healthy habits. Advances in testing and personalized medicine enable better management of epigenetic influences. Embracing balanced nutrition, regular exercise, and avoiding harmful exposures promotes beneficial epigenetics, supporting overall well-being and disease prevention.
