Introduction

Knee osteoarthritis (OA) is a common condition marked by pain, stiffness, and reduced mobility that affects millions worldwide, especially those over 45. Managing OA can be tough, partly because many treatments provide only temporary relief. Among the non-surgical options, injectable therapies like hyaluronic acid (HA) have been widely used, but their effects often last just a few months. Recently, a new injectable called Arthrosamid has emerged, offering the possibility of longer-lasting symptom relief. In this article, we’ll look at how Arthrosamid compares to traditional hyaluronic acid injections , so you can better understand the potential advantages and considerations of each.

What Is Viscosupplementation?

Viscosupplementation involves injecting a gel-like material into the knee joint to enhance the quality of the joint’s natural lubricating fluid— synovial fluid . In osteoarthritis , this fluid thins out, increasing friction and joint pain.

Hyaluronic acid injections aim to restore some of that lost cushioning and lubrication, making knee movement easier and less painful. Many people do experience noticeable relief, but the benefits can vary and often last between three and twelve months. Because of this, repeated injections are common, and for some, the results aren't as strong or long-lasting as hoped. Research has shown that hyaluronic acid can reduce pain and improve function, but not all patients respond in the same way.

What Makes Arthrosamid Different?

Arthrosamid takes a different approach. Instead of using hyaluronic acid, it contains polyacrylamide hydrogel , a soft, water-rich gel (about 97.5% water). Unlike hyaluronic acid, Arthrosamid doesn’t break down and get absorbed over time. Instead, it integrates into the soft tissue of the joint, providing a more lasting cushioning effect.

You can think of Arthrosamid as a gentle, long-term gel implant that pads and protects the joint, helping to absorb shock and reduce pain over a much longer period. Clinical studies suggest that a single Arthrosamid injection can offer relief that lasts up to one or two years. While research is ongoing to determine which patients benefit the most, results so far are promising.

How Do Arthrosamid and Hyaluronic Acid Compare in Clinical Practice?

The clinical evidence suggests Arthrosamid may deliver longer-lasting relief than hyaluronic acid injections . In studies involving hundreds of patients, Arthrosamid has been shown to significantly decrease pain and improve knee function for at least a year, and sometimes for up to two years after just one injection.

Traditional hyaluronic acid injections can also help with pain and mobility, but often need to be repeated more frequently because their effect fades in a few months. Both options are generally safe, with mild swelling or discomfort around the injection site being the most common short-term side effects.

Professor Paul Lee , a knee osteoarthritis specialist at MSK Doctors, notes that results are often best when treatments are provided in an experienced and supportive clinical setting. Choosing the right therapy should always involve a discussion between you and your healthcare team.

What Should Patients and Healthcare Professionals Consider?

Deciding between Arthrosamid and hyaluronic acid injections is not a one-size-fits-all situation. The severity of your osteoarthritis , your overall health, and personal preferences should all play a role.

Recent studies suggest that factors such as older age, a lower OA grade, not having diabetes, and having OA in both knees may predict better outcomes with Arthrosamid . Its main advantage is fewer injections over time, which can be more convenient for some. Still, it’s important to understand that neither treatment is a cure—every patient’s experience will be different, and realistic expectations are key.

It’s also important that your progress is monitored and follow-up care is planned. If you’re considering injectable therapy for your knee OA, talk to a healthcare provider who understands your specific needs and can help you make an informed choice.

For personalised medical advice, always consult a qualified healthcare professional.

Conclusion

Arthrosamid is an exciting new option for people with knee osteoarthritis , especially if you’re hoping for longer-lasting relief than hyaluronic acid injections typically provide. Its unique hydrogel formulation allows it to cushion and support the joint for an extended period, improving comfort and mobility.

Both Arthrosamid and traditional HA injections have a role to play in managing knee OA. The right option depends on your individual condition, preferences, and the advice of your healthcare team. As research continues, these treatments offer hope and improved quality of life for those living with osteoarthritis .