Demystifying the ChondroFiller Procedure

Miss Sophie Harris
Miss Sophie Harris
Published at: 17/10/2025

Demystifying the ChondroFiller Procedure

Introduction: Demystifying the ChondroFiller Procedure

Is the ChondroFiller procedure complicated? Many people wonder what’s involved in this innovative treatment for cartilage damage . In simplest terms, ChondroFiller is a one-step, cell-free collagen scaffold applied through keyhole surgery—meaning it uses tiny incisions for minimal disruption and, importantly, leaves your healthy cartilage intact.

At MSK Doctors, Professor Paul Lee leads a team with decades of experience in orthopaedics, offering a professional, caring environment for this advanced procedure. In this article, we’ll walk you through the ChondroFiller process step by step, cover potential challenges and key patient considerations, share expert insights from Professor Lee and his team, and finish with practical advice to help you make an informed decision.

Step-by-Step Guide to the ChondroFiller Procedure

The ChondroFiller procedure is thoughtfully planned and delivered in several clear steps designed to restore damaged cartilage :

  1. Patient Selection and Pre-operative Assessment
    Not every cartilage injury is suitable for this treatment. The best candidates have a localised cartilage defect without widespread joint damage. Before surgery, a detailed assessment of your knee and the extent of the defect helps confirm that ChondroFiller will be effective for you.
  2. Arthroscopic Preparation and Lesion Inspection
    The procedure begins with arthroscopy —a tiny camera is inserted through small incisions—allowing the surgeon to closely inspect the joint for any additional issues, such as meniscus tears , which can be treated at the same time.
  3. Careful Debridement While Preserving the Subchondral Plate
    Damaged or loose cartilage is gently removed using specialised tools, with special care taken to preserve the subchondral plate—the hard bone layer directly beneath the cartilage. Protecting this layer is crucial for the new scaffold to anchor properly.
  4. Drying the Defect and Precise Delivery of the ChondroFiller
    After cleaning, the area is dried to help the scaffold adhere well. The ChondroFiller —a cell-free collagen matrix warmed to body temperature—is then injected precisely into the defect under camera guidance. If the space is difficult to reach, a specialist technique using a curette and needle makes delivery easy and reliable.
  5. Matrix Hardening: Completing the Procedure
    The matrix begins to set within 5 to 15 minutes, creating a stable surface for new cartilage to grow over time. After this, the instruments are removed and the small incisions are closed.

Each of these steps is guided by robust clinical research, showing significant improvements in tissue repair and function for many patients.

Potential Challenges and Patient Considerations

While ChondroFiller is safe and minimally invasive, a few challenges may arise. Sometimes, the gel scaffold might not harden fully, especially in tricky-to-access areas like behind the kneecap. In rare cases, a small extra incision (mini-arthrotomy) may be needed for precise placement.

As with any surgery, there is a small risk of infection , but this is significantly reduced by strict hygiene protocols and the surgical expertise at MSK Doctors .

Post-surgery, following the correct aftercare is essential. Most patients have their knee immobilised in a plaster splint for the first two days, then start putting partial weight on the leg—about 20 kilograms—for six weeks using crutches . Depending on the defect’s location, a gradual program of gentle exercise and supportive devices helps the joint heal properly.

Clinical studies have shown high patient satisfaction, with many people safely returning to sports and daily activities. While every case is unique and outcomes can vary, the results so far are encouraging for both safety and effectiveness.

Expert Insights from Professor Paul Lee and MSK Doctors

Professor Paul Lee ’s extensive orthopaedic expertise ensures each patient receives personalised care at every stage. At MSK Doctors , a team of specialists supports patients from diagnosis and surgery through to rehabilitation.

Professor Lee notes that while the ChondroFiller procedure requires technical skill, it is well within the reach of experienced surgeons and offers real benefits to patients. Thanks to keyhole techniques and the collagen scaffold , healthy cartilage is preserved, and the overall experience is less invasive than traditional methods. While no surgery can guarantee a cure, ChondroFiller provides a promising option for many living with cartilage defects .

Conclusion and Responsible Advice

In summary, the ChondroFiller procedure may sound complex, but in the experienced hands of Professor Paul Lee and the MSK Doctors team, it’s a smooth, minimally invasive option for treating targeted cartilage defects. This approach combines the latest technology with a patient-first attitude to offer effective care.

For advice tailored to your needs, please consult a qualified healthcare professional. At MSK Doctors , your health and recovery remain the top priorities from start to finish.

References

Corain, M., Zanotti, F., Giardini, M., Gasperotti, L., Invernizzi, E., Biasi, V., & Lavagnolo, U. (2023). The Use of an Acellular Collagen Matrix ChondroFiller® Liquid for Trapeziometacarpal Osteoarthritis. https://doi.org/10.1177/19476035251354926
Perez-Carro, L., Mendoza Alejo, P. R., Gutierrez Castanedo, G., Menendez Solana, G., Fernandez Divar, J. A., Galindo Rubin, P., & Alfonso Fernandez, A. (2021). Hip Chondral Defects: Arthroscopic Treatment With the Needle and Curette Technique and ChondroFiller. Arthroscopy Techniques. https://doi.org/10.1016/j.eats.2021.03.011
De Lucas Villarrubi, J. C., Méndez Alonso, M. Á., Sanz Pérez, M. I., Trell Lesmes, F., & Panadero Tapia, A. (2021). Acellular Matrix-Induced Chondrogenesis Technique Improves the Results of Chondral Lesions Associated With Femoroacetabular Impingement. Arthroscopy. https://doi.org/10.1016/j.arthro.2021.08.022

Frequently Asked Questions

  • ChondroFiller at MSK Doctors uses a cell-free collagen scaffold applied via keyhole surgery, preserving healthy cartilage. Led by Professor Paul Lee, the team offers advanced expertise, using minimally invasive techniques for precise repair, aiming for reduced disruption and better outcomes for patients.
  • Suitable candidates are individuals with a localised cartilage defect, without widespread joint damage. Professor Lee and his team conduct thorough pre-operative assessments at MSK Doctors to ensure patients benefit most from the ChondroFiller approach, providing personalised and professional care.
  • Some challenges include incomplete hardening of the gel in difficult-to-access areas and, rarely, the need for an extra small incision. Like all surgeries, potential risks include infection, but MSK Doctors’ strict protocols and expertise help minimise such concerns for patients.
  • Professor Paul Lee’s extensive orthopaedic experience ensures patients receive highly personalised treatment plans. His technical skill, together with the MSK Doctors team’s support throughout diagnosis, surgery, and rehabilitation, creates an effective and reassuring environment for the ChondroFiller procedure.
  • After ChondroFiller, most patients have their knee immobilised briefly, then gradually resume weight-bearing using crutches. The MSK Doctors team guides gentle rehabilitation tailored to each patient, supporting a safe return to daily activities with high satisfaction rates, under Professor Lee’s expert supervision.

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