Top Risk Factors for Osteoarthritis: Age, Obesity, Injury, and Inflammation Explained

Miss Ella McAleese
Miss Ella McAleese
Published at: 21/11/2025

Top Risk Factors for Osteoarthritis: Age, Obesity, Injury, and Inflammation Explained

What Are the Main Risk Factors for Osteoarthritis?

Osteoarthritis is a degenerative joint disease characterised by the breakdown of cartilage and underlying bone, which results in pain and stiffness. Recognising the biggest risk factors of osteoarthritis can help individuals adopt strategies to prevent or slow its onset. While age is often cited as the predominant cause, many other factors have a profound influence on joint health. Overweight and obesity place excess pressure on weight-bearing joints like the knees and hips, accelerating cartilage wear. Smoking, surprisingly, also increases the risk, as it contributes to low level inflammation and undermines the natural repair processes of the body. Sustaining a previous injury, whether due to sports, an accident, or repetitive movements, can disrupt joint function and expedite osteoarthritic changes. Additionally, diet and lifestyle choices 6such as a lack of physical activity and poor nutrition 6can further increase susceptibility. Early recognition and intervention are crucial, as ignoring early signs of joint pain or stiffness can allow the condition to worsen undetected.

Obesity, Diet and Lifestyle 6 A Vicious Cycle

One of the most significant risk factors for osteoarthritis is being overweight. Extra kilograms multiply the force placed on weight-bearing joints during normal activities, hastening cartilage degeneration. Beyond mechanical stress, obesity is often linked with increased levels of low level inflammation in the body 6a key contributor to cartilage breakdown. Choices in diet and lifestyle play a significant role as well. Diets high in saturated fats, processed foods and sugars can fuel inflammation, while antioxidant-rich foods, healthy fats, and regular exercise may provide protection. Smoking compounds these effects: it reduces blood flow to joint tissues, interferes with cartilage healing, and perpetuates inflammation. By focusing on weight management and adopting an anti-inflammatory diet and lifestyle, patients can meaningfully lower their osteoarthritis risk and improve their overall joint health.

How Previous Injury Influences Osteoarthritis Risk

A history of previous injury, particularly to key joints like the knee or hip, is a significant independent risk factor for osteoarthritis. Trauma can result in subtle but lasting damage to the cartilage, bone or ligaments, creating abnormal joint mechanics and accelerated wear over time. For example, a torn anterior cruciate ligament (ACL) or meniscus in the knee often increases the likelihood of developing osteoarthritis, even after surgical repair. Returning too quickly to activity after injury, or failing to undergo proper rehabilitation, may prolong joint instability and hasten the onset of symptoms. Ignoring early signs 6such as joint pain, swelling, clicking, or intermittent instability 6can worsen outcomes. Early intervention after injury, including physical therapy, weight management, and monitoring, can help reduce the risk. Patients who have sustained previous injuries should be proactive, seeking medical advice for any recurrent or persistent symptoms, and adopt measures that support joint health long-term.

Low Level Inflammation: The Hidden Aggravator

While osteoarthritis is primarily considered a wear-and-tear condition, mounting evidence links low level inflammation to its progression. Obesity, sedentary lifestyle, poor diet and smoking all contribute to a persistent, mild inflammatory state in the body. This subtle inflammation does not usually cause obvious symptoms, but it has significant effects at the cellular level within the joint. Inflammatory molecules released in the body can break down cartilage and prevent its natural repair, increasing joint vulnerability over time. Managing inflammation through targeted changes in diet and physical activity, avoidance of smoking, and effective management of metabolic conditions like diabetes can significantly impact the course of osteoarthritis. Understanding the role of low level inflammation empowers individuals to make informed choices that reduce their risk, rather than passively accepting gradual joint degradation as an inevitable aspect of ageing.

FAQ: Biggest Risk Factors of Osteoarthritis

Does being overweight really increase my risk of osteoarthritis?

Yes, excess body weight increases the load on weight-bearing joints such as the knees and hips, accelerating cartilage breakdown and triggering inflammation, which both raise your risk of developing osteoarthritis.

What role does previous injury play in osteoarthritis?

Previous injuries to joints 6such as sports injuries, fractures or ligament tears 6can damage cartilage or disrupt joint stability. These changes accelerate joint wear, making it more likely for osteoarthritis to develop at the injury site, sometimes years later.

Can lifestyle and diet really make a difference?

Absolutely. Diets rich in fruits, vegetables, healthy fats, and lean proteins can reduce inflammation, while regular exercise helps maintain a healthy weight and supports joint function. Healthy lifestyle choices are powerful protective tools against osteoarthritis.

Is low level inflammation really that important?

Yes, chronic low level inflammation can damage cartilage over time. Factors like poor diet, lack of exercise, metabolic conditions, and smoking all contribute to this, highlighting the importance of reducing systemic inflammation to protect joint health.

Does smoking raise my risk for osteoarthritis?

Yes, smoking is a recognised risk factor. It reduces blood supply to joint tissues, interferes with cartilage healing, and promotes inflammation, all of which can increase your osteoarthritis risk.

Should I be concerned if I have ignored early signs of joint pain?

Ignoring early symptoms such as pain, stiffness, or swelling can allow osteoarthritis to progress unchecked, making treatment more complex. If you experience persistent joint symptoms, seek advice promptly to improve your outcome and reduce complications.

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Always seek personalised advice from a qualified healthcare professional before making decisions about your health. MSK Doctors accepts no responsibility for errors, omissions, third-party content, or any loss, damage, or injury arising from reliance on this material.

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