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ChondroFiller IKDC and MOCART scoresChondroFiller patients' functional-outcome scores (IKDC) gain approximately 30 points within 12 months, rising from ~48 to ~80, whilst structural MRI (MOCART) markers advance from 65 to 81–84 — dual tracks converging on tissue repair and restored joint function.ChondroFiller patients' functional-outcome scores (IKDC) gain approximately 30 points within 12 months, rising from ~48 to ~80, whilst structural MRI (MOCART) markers advance from 65 to 81–84 — dual tracks converging on tissue repair and restored joint function.
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OCA or MACI for large knee cartilage defectsWhen subchondral bone is damaged alongside large knee cartilage defects, OCA — a single-stage transplant of donor bone and cartilage — is the preferred choice; MACI, which implants cultured cells, cannot restore bone stock once lost.When subchondral bone is damaged alongside large knee cartilage defects, OCA — a single-stage transplant of donor bone and cartilage — is the preferred choice; MACI, which implants cultured cells, cannot restore bone stock once lost.
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ChondroFiller NHS status and private access in the UKChondroFiller, an ultrasound-guided collagen scaffold that improves IKDC knee scores by roughly 30 points over 12 months, is unavailable on the NHS not for safety reasons but because it has not undergone formal commissioning appraisal. Private UK access costs £3,000–£9,500.ChondroFiller, an ultrasound-guided collagen scaffold that improves IKDC knee scores by roughly 30 points over 12 months, is unavailable on the NHS not for safety reasons but because it has not undergone formal commissioning appraisal. Private UK access costs £3,000–£9,500.
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Autograft or allograft for large knee cartilage defectsKnee cartilage defects smaller than roughly 2 cm² are typically repaired with the patient's own tissue; larger defects require fresh donor grafts because the knee lacks sufficient low-load surface to harvest from safely.Knee cartilage defects smaller than roughly 2 cm² are typically repaired with the patient's own tissue; larger defects require fresh donor grafts because the knee lacks sufficient low-load surface to harvest from safely.
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Allograft vs autograft for large knee cartilage defectsAutograft for knee cartilage defects larger than roughly 2–4 cm² risks replacing one area of cartilage loss with another at the harvest site. Osteochondral allografts from cadaveric donors eliminate this trade-off and achieve 5-year survival of 79–87.8%.Autograft for knee cartilage defects larger than roughly 2–4 cm² risks replacing one area of cartilage loss with another at the harvest site. Osteochondral allografts from cadaveric donors eliminate this trade-off and achieve 5-year survival of 79–87.8%.
