Choosing injection treatments for knee, hip and ankleHyaluronic acid injections can ease knee osteoarthritis pain for months, but the 2019 ACR/AF guideline recommends against routine use for knee disease and strongly against it for hip disease because average benefit is modest. Microfragmented fat and bone marrow concentrate are more experimental biologic options, with limited evidence and narrower…Hyaluronic acid injections can ease knee osteoarthritis pain for months, but the 2019 ACR/AF guideline recommends against routine use for knee disease and strongly against it for hip disease because average benefit is modest. Microfragmented fat and bone marrow concentrate are more experimental biologic options, with limited evidence and narrower uses in knee arthritis and talar cartilage lesions.