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Understanding the Causes of Ankylosing Spondylitis: Genetic and Environmental Factors
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Tanvi Verma
5/5/2025
Understanding the Causes of Ankylosing Spondylitis: Genetic and Environmental Factors
Ankylosing spondylitis is a chronic inflammatory condition affecting the spine and sacroiliac joints, characterized by persistent back pain and stiffness. The disorder is linked to genetic factors, notably the HLA-B27 gene, but environmental influences also play a vital role in its development. Symptoms often worsen in the morning or after…Ankylosing spondylitis is a chronic inflammatory condition affecting the spine and sacroiliac joints, characterized by persistent back pain and stiffness. The disorder is linked to genetic factors, notably the HLA-B27 gene, but environmental influences also play a vital role in its development. Symptoms often worsen in the morning or after inactivity, with potential complications including spine fusion and organ involvement, affecting the eyes, heart, and lungs. Early diagnosis through medical history, imaging, and blood tests is crucial for management. While there's no cure, treatments like NSAIDs and exercises can alleviate symptoms and maintain mobility. Preventative strategies involve an active lifestyle and weight management. Timely intervention is essential to prevent severe complications and improve quality of life. Research continues to explore more effective therapies for this debilitating disease. For more insights on diagnosis, management, and living with ankylosing spondyli
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