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The Connection Between Chronic Inflammation and Bone LossChronic inflammation, common in conditions like rheumatoid arthritis and lupus, significantly impacts bone health by accelerating bone loss and increasing osteoporosis risk. This article explores the mechanisms behind bone resorption versus formation imbalance due to inflammatory cytokines, and the role of glucocorticoids in exacerbating bone density reduction. Rheumatoid arthritis, inflammatory…Chronic inflammation, common in conditions like rheumatoid arthritis and lupus, significantly impacts bone health by accelerating bone loss and increasing osteoporosis risk. This article explores the mechanisms behind bone resorption versus formation imbalance due to inflammatory cytokines, and the role of glucocorticoids in exacerbating bone density reduction. Rheumatoid arthritis, inflammatory bowel disease, lupus, and psoriasis are highlighted for their contribution to bone health deterioration. The article also discusses prevention strategies, including a diet rich in calcium and vitamin D, weight-bearing exercises, regular bone density testing, and medication options like bisphosphonates. Minimising glucocorticoid use is crucial for managing bone health. For those with chronic inflammatory conditions, understanding these connections and implementing protective measures can help maintain stronger bones. Discover more about managing bone health amid chronic inflammation at MSK Docto
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From Genetics to Epigenetics: Navigating the Complex Landscape of InheritanceEpigenetics describes the study of changes in gene activity and expression without altering the DNA sequence, influencing development and health conditions such as cancer and autoimmune diseases. Environmental factors and lifestyle choices can induce adverse epigenetic changes, potentially leading to chronic illnesses like multiple sclerosis or lupus. Recovery through lifestyle…Epigenetics describes the study of changes in gene activity and expression without altering the DNA sequence, influencing development and health conditions such as cancer and autoimmune diseases. Environmental factors and lifestyle choices can induce adverse epigenetic changes, potentially leading to chronic illnesses like multiple sclerosis or lupus. Recovery through lifestyle adjustments, such as diet and exercise, is crucial, although results can take months to manifest. Early intervention, regular health screenings, and professional medical advice are vital for monitoring and managing detrimental epigenetic effects. While some genetic factors are unavoidable, many lifestyle-related changes can be mitigated. Maintaining healthy habits and making informed lifestyle modifications, with healthcare supervision, can significantly improve health outcomes by positively impacting gene expression.
