What to Expect on Injection Day: A Patient’s Guide to Chondroitin Injections

Miss Sophie Harris
Miss Sophie Harris
Published at: 1/10/2025

What to Expect on Injection Day: A Patient’s Guide to Chondroitin Injections

Introduction

Chondroitin injections are a widely used treatment to support joint health, especially for people coping with osteoarthritis or similar conditions caused by joint wear and tear. These injections work by delivering chondroitin , a natural compound found in cartilage, directly where it’s needed—helping reduce pain and promote smoother movement. The day you receive your injection—often called injection day—is an important milestone in your treatment. Knowing what to expect can make things feel less intimidating and help you prepare both mentally and physically. In this guide, we’ll take you through every step: how to get ready, what happens during the injection, and the best ways to take care of yourself afterward—all informed by the latest medical advice and research.


Getting Ready for Injection Day

A bit of preparation can make injection day go much more smoothly. Your doctor may ask you to stop certain medications, like blood thinners, a few days before the procedure to lower your risk of bleeding.

It’s helpful to eat a light, nutritious meal before your appointment, so you don’t feel faint or uncomfortable during the procedure. Before your injection, you’ll have a consultation where your healthcare provider reviews your medical history, checks for allergies, and discusses any past reactions to similar treatments. Following your provider’s instructions not only personalizes your care, but also makes the process easier for both you and your clinician.

Let your doctor know about any other medications or treatments you’re using, including hormone therapies, as these can sometimes influence how your body responds to injections.


What Happens During the Injection?

When you arrive at the clinic or hospital, a healthcare professional will explain the procedure and answer any last-minute questions you might have. The area over your joint will be cleaned to prevent infection, and you’ll be positioned so the joint is easy to access and you’re as comfortable as possible.

The injection itself uses a fine needle—it’s a quick process and usually only causes brief discomfort. The chondroitin is delivered directly into the joint space, and most appointments are over in just a few minutes.

Research has shown that combining chondroitin sulfate with other treatments like hyaluronic acid can further improve joint mobility and comfort, without increasing the risk of serious side effects. Most people tolerate the procedure well, and adverse reactions are rare.


Looking After Yourself After the Injection

After your injection, take it easy for the next 24 hours to give your joint time to rest. Mild swelling or tenderness around the injection site is common—using a cold pack can help if you feel any discomfort.

Watch for signs of infection, such as unusual redness, increasing pain, warmth around the joint, or fever. If you notice any of these, reach out to your doctor right away.

The good news: clinical studies report a significant reduction in pain levels after chondroitin injections , with many people experiencing improvement as early as six weeks—and even greater mobility increases after several months. However, everyone’s response and recovery time can be a bit different, so patience is key as your body heals.

Your doctor may schedule a follow-up appointment to monitor your progress and decide if you need additional injections in the future. In the meantime, gentle activities like walking or swimming are encouraged to keep your joint flexible—but hold off on strenuous exercise until you’ve fully recovered.


Conclusion

Injection day is an important step in improving your joint health with chondroitin therapy . By preparing ahead, understanding the process, and caring for yourself afterward, you’ll boost your chances of success and reduce any risks.

Knowing what to expect can help you feel more confident and at ease throughout your treatment journey. With the right approach, chondroitin injections can become a valuable part of your plan for more comfortable and flexible joints.


References

Dima, A., Dragosloveanu, M., Romila, A. R., Cristea, A., Marinică, G., Dănilă, A.-T., Mandici, A., Cojocariu, D., Vlad, R.-A., Ciurba, A., & Bîrsan, M. (2024). Can Hyaluronic Acid Combined with Chondroitin Sulfate in Viscosupplementation of Knee Osteoarthritis Improve Pain Symptoms and Mobility? Biomolecules, 14(7), 832. https://doi.org/10.3390/biom14070832
Clark, M. J. (1968). Termination of embryonic diapause in the red kangaroo, Megaleia rufa, by injection of progesterone or oestrogen. Reproduction, 15(3), 347-355. https://doi.org/10.1530/jrf.0.0150347
Putz, A., Bazin, B., & Pedron, B. M. (1994). Commercial polymer injection in the Courtenay field, 1994 update. . SPE. https://doi.org/10.2118/28601-ms

Frequently Asked Questions

  • MSK Doctors stands out for offering cutting-edge therapies led by Prof Lee, who has significant expertise in chondroitin injections. The clinic provides evidence-based, personalised care and utilises the latest research to guide effective treatments for joint-related conditions.
  • Before your injection at MSK Doctors, Prof Lee’s team will review your medications and medical history. You may be asked to stop certain drugs. Eating a light meal and sharing all your current treatments ensures your experience is as safe as possible.
  • During your appointment, Prof Lee or an experienced MSK Doctors clinician thoroughly explains the procedure. The injection uses a fine needle and is performed quickly, with cleanliness and your comfort prioritised. The approach draws on MSK Doctors’ expertise in musculoskeletal care.
  • Most people feel only mild swelling or tenderness, which can be eased with a cold pack. Serious reactions are rare. MSK Doctors will schedule follow-ups to track your progress, and Prof Lee’s team is always available if you have concerns post-injection.
  • Prof Lee is internationally recognised for musculoskeletal medicine and brings years of specialised experience. MSK Doctors, under his guidance, combines advanced treatments and a patient-centred approach, aiming to optimise outcomes for joint pain and mobility challenges.

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This article is written by an independent contributor and reflects their personal opinions and professional experience. It does not necessarily represent the views of MSK Doctors. All guest submissions are published in good faith, and MSK Doctors does not verify the accuracy of claims, the clinical content, or the legal ownership of any images or media submitted.

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